He is noted for some of Copenhagen’s most iconic buildings including Radiohus, Folkets Hus (now Vega) and the now defunct Terminal 2 at Copenhagen Airport, all of which are today listed. Radiohus, designed to headquarter the national broadcaster, DR, and today the Royal Danish Music Conservatory, stands as a proud symbol of Danish functionalism and modernism. Lauritzen’s first sketches for the building were drawn in 1934, which was built between 1936 and 1941 and officially inaugurated in 1945 after the end the Second World War. Today, Radiohuset is regarded as one of the architectural masterpieces of the 20th century.

Radiohus was a gesamtkunstwerk. Vilhelm Lauritzen designed everything from door handles, railings and ashtrays to lamps, sofas and counters, in close collaboration with Finn Juhl, who was employed under Lauritzen from 1934 to 1945. The Radiohus sofa was designed in 1936 for the foyer of the building. Profiling a new, soft Nordic functionalism, the sofa is a fusion of the two designers’ sensibilities: Juhl’s organic and sculptural idiom and Lauritzen's stringent functionalism. In addition to his modernist and functionalist building designs, Vilhelm Lauritzen created a number of iconic furniture pieces and lamps.